Innovita Research Foundation

I.R.F. / Aging news / Cloning / 03010201

Future Medicine Nowadays
Posted on: January 2, 2003

New approaches to the cancer treatment are on the way. All previous methods for treating cancer in near future could be supplemented with new one. In nowadays we use chemotherapy, radiotherapy transplantation to treat various cancer forms. Chemotherapy kills not only tumor cells, but also other normal dividing cells, causing a hardly repairable damage to all organism. Beside tumors proved resistant to chemotherapy. And there was little hope of killing such widespread growth with conventional radiotherapy. To lower the damage caused by drugs and harmful procedures used in cancer treatment to all organism scientists have treated cancer by removing an entire organ, administering radiotherapy and re-implanting it back into the body. The Boron neutron capture was used, by injecting boron atoms into the cancerous organ, and using a neutron beam to split them into destructive high-energy particles. Cancer cells grow faster than normal cells, and so take up more boron atoms. This means that they are more likely to be destroyed when the neutron beam is switched on, and when this procedure is applied to the entire cancerous organ when it is removed from organism the damage to other organs is lowered to the minimum. After beaming procedure organ is transplanted back into the organism. What is promising, that such procedure have already been used on the patient with multiple liver cancer, and it resulted in a very fine recovery. In near future in vitro organ surgery procedure could be used not only in cancer treatment. One could develop the methods of organ genetic engineering, cell therapy and other molecular modifications procedures to recover the lost function of organ. One more promising therapy is organ cultivation from xenogenous species. The example could be recent success to grow human kidneys in mice, and pig. By taking the organ precursor cells from patient a "master" cell that has the ability to divide and become all the different types of cell required to form a fully-grown organ. Both porcine (pig) and human versions of these cells were taken and transplanted into mice. Both types developed into perfect organs at an appropriate size for a mouse. They produced urine and were supplied with blood by vessels from the host. In addition, there was no dangerous immune response to the new organs - scientists believe because the cells were taken early in foetal development (from aborted fetuses of 7-8 weeks, low MHC-I expression levels), cells which would normally trigger the immune system were not present. Only one problem could be retroviruses present in pigs, which could recover then passed to human organism. Some more advantageous procedures should be developed to ensure the safety of the patient. Age related diseases, senescence could be influenced and treated by renovating wore-out organs in the similar way. Until then, much more research should be processed.

Source: 2002-12; Science 2002
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