Innovita Research Foundation

I.R.F. / Aging news / Cloning / 02080401

Perspectives for ES Cells
Posted on: August 4, 2002

Robl* et al. have developed a method, using nuclear transplantation, to produce transgenic embryonic stem (ES)-like cells from fetal bovine fibroblasts. These cells, when reintroduced into preimplantation embryos, differentiated into derivatives from the three embryonic germ layers, ectoderm, mesoderm, and endoderm, in 5-month-old animals. Six out of seven (86%) calves born were found to be chimeras for at least one tissue. These experiments demonstrate that somatic cells can be genetically modified and then de-differentiated by nuclear transfer into ES-like cells, opening the possibility of using them in differentiation studies and human cell therapy.

Source: *Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst 01003, USA.
   | Next >