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I.R.F. / Aging news / General / 11082902

Change of Physiological Parameters During Aging
Posted on: August 29, 2011

The aim of the work was to study sex-specific differences between certain risk factors of cardiovascular diseases and hemodynamic parameters in elderly subjects and their relation to age-specific diseases and genealogic history of longevity.

Total cholesterol, triglyceride, glucose, fibrinogen, uric acid, urea, creatinine levels in plasma and arterial pressure (AP) were measured. Hemodynamic parameters were calculated by the formulas for the stroke volume, cardiac output, myocardial contractility, pulse pressure, total peripheral resistance (TPR), endurance factor of cardiac activity, and Kerdo index.

Each new decade of life was characterized by peculiar hemodynamic patterns. Pulse AP (PAP) and TPR increased with age and was associated with sex-related metabolic changes. Elderly men presented with hypocholesterolemia and anemia. Total cholesterol, fibrinogen, and glucose levels did not correlate with age.

To conclude, elevated PAP, TPR, and left ventricular hypertrophy are risk factors of cardiovascular diseases in old subjects. Combination of several risk factors in young and middle-age subjects reduces prognostic value of the longevity factor in the familial history. Aging is accompanied by the development of gender-related differences in metabolic parameters.

Source: Aging, age-related diseases, and certain risk factors of cardiovascular diseases in subjects of advanced and senile age.; Klin Med (Mosk). 2011;89(3):21-7.
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