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Accumulation of Damage at the Nuclear Pore Complexes Might be a Crucial Aging Event
Posted on: February 21, 2022

In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic cells is unknown.

Scientists found that NPCs, unlike other nuclear structures, do not turn over in differentiated cells. While a subset of NPC components, like Nup153 and Nup50, are continuously exchanged, scaffold nucleoporins, like the Nup107/160 complex, are extremely long-lived and remain incorporated in the nuclear membrane during the entire cellular life span. Besides the lack of nucleoporin expression and NPC turnover, they discovered an age-related deterioration of NPCs, leading to an increase in nuclear permeability and the leaking of cytoplasmic proteins into the nucleus.

The finding that nuclear "leakiness" is dramatically accelerated during aging and that a subset of nucleoporins is oxidatively damaged in old cells suggests that the accumulation of damage at the NPC might be a crucial aging event.

Source: D'Angelo MA, Raices M, Panowski SH, Hetzer MW.; Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells.; Cell. 2009 Jan 23;136(2):284-95.
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